The ankle is very painful for no reason generally can take anti-inflammatory and analgesic drugs, drugs to improve microcirculation and topical drugs, to choose the appropriate drugs for treatment, so as not to delay the condition. 1. Anti-inflammatory and analgesic drugs: you can take celecoxib capsules, meloxicam tablets, ibuprofen, indomethacin, diclofenac sodium and other non-steroidal anti-inflammatory drugs as prescribed by the doctor, can alleviate the symptoms, if the patient has gastrointestinal tract disease, generally choose to gastrointestinal tract stimulation of the small celecoxib capsule, Erythroxib tablets, etc. for treatment. 2. Drugs to improve microcirculation: such as Mai Zhi Ling, sodium heptaphyllum saponin and other drugs can help promote blood circulation, reduce swelling, can be taken under the guidance of a doctor. 3. Topical medications: Yunnan Baiyao aerosol and diclofenac diethylamide emulsion can be applied to the ankle area to help reduce inflammation and analgesia, activate blood circulation and remove blood stasis, and relieve pain. 4. Sudden pain in the ankle needs to exclude the possibility of gout. You can take colchicine, allopurinol, benzbromarone and other drugs to lower uric acid. All of the above medications should be used under the guidance of a doctor, avoid self-medication to avoid adverse reactions.