Treatment of Helicobacter pylori infection with lower limb edema, firstly, to clarify whether it is an adverse drug reaction, and secondly, to consider the existence of other conditions, such as prolonged standing, heart failure, varicose veins of the lower limbs, and so on. 1. Adverse drug reactions: according to the specific drugs, the adverse reactions are different. Common drugs include proton pump inhibitors (e.g., omeprazole, lansoprazole), antibiotics (e.g., amoxicillin, clarithromycin), and bismuth (e.g., colloidal bismuth pectin, bismuth potassium citrate). 2. Other causes: (1) Physiological causes: e.g., excessive drinking before bedtime, prolonged standing, etc., can lead to transient lower limb edema. (2) Pathological causes: cardiogenic edema caused by heart failure, pericarditis, etc.; nephrogenic edema caused by glomerulonephritis, nephrotic syndrome, etc.; hepatic edema caused by viral hepatitis, cirrhosis, etc.; localized edema caused by varicose veins of the lower extremities, dengue, etc. If edema of the lower extremities occurs during the administration of medication for H. pylori infection, it is recommended to consult a doctor to clarify whether the medication is the cause.