Pyloric duct ulcers often lack the periodic and rhythmic pain of typical ulcers, postprandial epigastric pain is common, poor response to antacids, easy vomiting or pyloric obstruction, and more complications such as perforation or bleeding. Differential diagnosis of pyloric ulcer: 1. duodenal ulcer: duodenal ulcer is a common disease of the gastrointestinal tract, generally believed to be due to the cerebral cortex after receiving external adverse stimuli, resulting in spasm of the blood vessels and muscles of the stomach and duodenal wall, so that the gastrointestinal wall cell nutrition is impaired and the resistance of the gastrointestinal mucosa is reduced, resulting in the gastrointestinal mucosa susceptible to digestion by gastric juices and the formation of ulcers, which is currently believed to be Campylobacter gastric The ulcer is often single, but there are also multiple ulcers, gastric and duodenal bulb ulcers, when existing at the same time is called compound ulcers. 2, gastric ulcer: gastric ulcer is a common disease of the digestive system, its typical manifestations are hunger discomfort, fullness belching, acidity or chronic pain in the upper middle abdomen at regular intervals after meals, in severe cases there can be black stool and vomiting blood. The more obvious causes are H. pylori infection, the use of non-steroidal anti-inflammatory drugs (NSAID) and excessive secretion of gastric acid; it can also be caused by genetic factors and mood swings, overexertion, eating disorders, smoking, alcohol abuse and other factors. Gastric ulcer because of the prolonged and complex condition, and mental and emotional related, aggravation or untimely treatment, but also lead to bleeding, perforation, pyloric obstruction and cancer and other adverse consequences, serious health hazards, so should be attached great importance.