Staying up late can cause elevated bilirubin and induce jaundice. Staying up late for a long time can lead to dull yellow skin, poor skin condition, and a series of diseases, especially in the digestive system, gallbladder, and stomach, which are all affected organs. Patients are prone to gallbladder polyps, gallstones, and cholecystitis, all of which can induce obstructive jaundice due to poor bile drainage. The cause of elevated bilirubin caused by staying up late should be treated. Especially for gallbladder disease and premature disintegration of red blood cells in the blood should be treated as an adjunct, reasonable choice of antibiotics, control of diet and attention to rest can make the condition improve and make the bilirubin elevation correct.