Treatment for hemolytic disease varies depending on the cause of the disease. Treatments include splenectomy, blood transfusion, medication, and blood exchange. Hemolytic disease is caused by the destruction of red blood cells due to various reasons and shortens their life span. If it is autoimmune hemolytic anemia, it can be treated with surgery to cut the spleen or with glucocorticoids. If it is caused by genetic factors such as thalassemia, it can be treated with blood transfusion, bone marrow transplantation, or splenectomy. It can also be treated with drugs such as danazol, gammaglobulin, rapamycin, and rituximab. Hemolytic disease in newborns can be treated with phototherapy or gammaglobulin injections, which are not effective, and blood exchange can also be considered. The causes of hemolysis are many and varied and cannot be listed here. If symptoms of hemolysis occur, you should consult the hematology department in time to clarify the cause of the disease and follow the doctor’s instructions for standardized treatment.