Positive pepsinogen generally refers to the decrease of pepsinogen, which may be caused by chronic gastritis, gastric ulcer, Helicobacter pylori infection and so on. 1. Chronic gastritis: patients with chronic gastritis will have decreased pepsinogen due to the damage of gastric mucosa, which leads to certain changes in pepsinogen content. 2. Peptic ulcer: for example, gastric ulcer, duodenal ulcer, etc., the patient’s gastric mucosa will have different degrees of damage, which will lead to a positive reduction of pepsinogen. 3. Helicobacter pylori infection: it is a kind of bacteria closely related to gastric diseases, which may lead to the decrease of pepsinogen, and if the infection is persistent, it may also lead to the formation of gastric cancer. Positive pepsinogen should cooperate with your doctor for further examination to clarify which kind of disease is causing the problem and then target treatment.