The treatments for melanosis of cheeks include general treatment, medication, chemotherapy, physical therapy and so on. 1. General treatment: Melanosis should actively search for the causes, such as primary diseases, excessive sun exposure and so on. Those who suffer from primary diseases should actively treat the primary diseases to reduce the melanin deposition of the skin. In daily life, attention should be paid to strict sunscreen to reduce melanin deposition. At the same time, attention should be paid to maintain a good state of mind, avoid staying up late, and ensure sufficient sleep time. 2. Drug treatment: can be used externally decolorizing agents such as hydroquinone cream, tretinoin, azelaic acid cream, compound arbutin cream, etc., which can inhibit the activity of tyrosinase and reduce the production of melanin. Topical retinoic acid ointment can also affect melanin metabolism and have a certain improvement effect on hyperpigmentation. If necessary, oral vitamin C, vitamin E and tranexamic acid can also be taken to reduce melanin deposition. 3. Physical therapy and auxiliary treatment: laser treatment such as carbon dioxide laser, Q laser, emerald green gemstone laser, etc. can break the pigment particles through high energy, which can also improve the skin melanosis. Fruit acid, salicylic acid and other chemical peeling also have a certain effect on the improvement of skin melanosis. It is recommended that patients with skin melanosis choose the appropriate treatment under the guidance of a doctor in conjunction with their own needs, and do not use medication on their own.