Severe abdominal pain may be caused by acute gastritis, pancreatitis, intestinal obstruction, etc., and need to be targeted to take general treatment, omeprazole, aluminum thiogluconate, norfloxacin, oxytetracycline and other medications, surgical treatment and so on. 1. Acute gastritis: mainly manifested as epigastric pain, caused by excessive secretion of gastric acid, generally need to take acid-suppressing drugs, such as omeprazole, rabeprazole, and with the gastric mucosal protective agents, such as aluminum thioglycollate, magnesium aluminium carbonate, etc., to be able to neutralize gastric acid and alleviate the pain symptoms. 2. Acute pancreatitis: the pain usually occurs in the left middle and upper abdomen, when the disease attacks, we need to pay attention to fasting and gastrointestinal decompression, the use of octreotide and other drugs to inhibit secretion of pancreatic enzymes, combined with the use of antibiotics, such as norfloxacin, levofloxacin, and with the inhibition of gastric acid drugs. 3. Intestinal obstruction: it may be caused by intestinal adhesion or tumor, which will trigger paroxysmal abdominal colic, and most of them need to take surgical treatment to release the obstruction or remove the tumor. In addition, severe abdominal pain may also be caused by other systemic diseases such as purpura, myocardial infarction. Severe abdominal pain should be immediately to the hospital to identify the cause of targeted treatment to avoid delay in treatment.