Necrotizing lymphadenitis, also known as histiocytic necrotizing lymphadenitis and subacute lymphadenitis, with an unknown pathogenesis, is a non-neoplastic lymph node enlargement disease, which is a reactive hyperplastic lesion of lymph nodes. Necrotizing lymphadenitis is most common in young adults in China, Japan, Korea, Vietnam and other eastern countries, with slightly more female patients than male patients. The main clinical manifestations are persistent high fever (usually for 1-2 weeks), enlarged liver, spleen and lymph nodes (mostly in the neck), or accompanied by hemorrhage, jaundice, rash, etc., and often accompanied by symptoms of cold, and the laboratory indexes can be seen in the mild decline of white blood cells, which is often suspected to be a malignant hematological disease, such as leukemia and lymphoma. For tissue necrotizing lymphadenitis, it is important to take more vitamins and take precautions. Once the above symptoms appear, you should go to the hospital in time to get a clear diagnosis and active treatment. The disease is ineffective in antibiotic treatment, and corticosteroid treatment is effective, with a tendency of self-healing and a very low recurrence rate.