Auricularia auricula is toxic, and its toxicity is mainly manifested as liver and kidney toxicity. Cynodonopsis can cause growth damage, causing azotemia, but also can make the liver congestion, fatty degeneration, resulting in severe damage to liver function, secondary cerebral edema, tonic spasm, severe can lead to death. Auricularia auricula has some other toxic effects: such as auricularia allergy leading to exfoliative dermatitis; auricularia auricula contains pepper toxin can cause liver damage; the phytotoxic proteins contained in the gastrointestinal mucosa has a stimulating and corrosive effect, which can cause internal hemorrhage. Cang Er Zi poisoning is mainly due to excessive dosage and improper concoction, the use of special attention should be paid to the amount of dosage, should not be taken in excess, the use of de-pricked. The use of Cang Er Zi appeared unsuitable as soon as possible to seek medical treatment.