In the development of kidney disease to the end stage, which is uremia, renal replacement therapy is needed. At present, the most common one in China is hemodialysis, which works by draining the blood from the body and cleaning out the excess water and toxins from the body through the filtration membrane of the dialyzer to achieve the internal environment, electrolyte and acid-base balance. Most of the dialysis patients in the clinic are caused by chronic renal failure. The dialysis method should choose hemodialysis + hemofiltration, and the choice of dialyzer is preferably a high-throughput dialyzer, which can not only remove small molecules of toxins (creatinine urea, etc.), but also have a certain ability to remove medium and large molecules of toxins (microglobulin, etc.), so as to better clarify the metabolic waste in the body and improve the quality of life, and adequate dialysis, which requires 3 times a week for 4 hours each time, regular oral administration of iron, erythropoietin, calcium, and osteopontin on top of dialysis to prevent nephrogenic anemia and nephrogenic bone disease and to improve the quality of life. The current dialysis technology allows patients to have an average survival of 20 years, so during the non-dialysis period, they are encouraged to go to work and work, live and study like normal people.