The side effects of ganoderma lucidum spore powder are as follows: First, for children, it can lead to developmental problems and induce allergies in children, which must be noted, especially because the immune system of children is not perfect, and the application of ganoderma lucidum spore powder can interfere with the normal metabolism of children. The second point, pregnant women, the application of Ganoderma spore powder is not recommended for pregnant women to avoid strong side effects, which may affect the pregnant woman and the fetus, and even lead to enhanced movement of the uterus and the risk of miscarriage. The third point is that in patients with severe liver and kidney deficiency, mostly seen with cirrhosis or kidney failure, the application of ganoderma lucidum spore powder will lead to an obvious increase in organ failure and a decrease in quality of life. The application of Ganoderma spore powder in clinical practice is best carried out rationally under the guidance of professionals.