Monkeypox virus is found in nature mainly in rodents in Africa (African squirrels, tree squirrels, Gambian kangaroos, dormice, etc.). Primates (monkeys, chimpanzees, humans, etc.) can also become infected after coming into contact with rodents infected with monkeypox virus. Animals infected with monkeypox virus and patients with monkeypox are the source of infection for this disease. Monkeypox virus invades the body mainly through mucous membranes and broken skin. Humans become infected mainly through contact with respiratory secretions, lesion exudates, blood, and other body fluids of infected animals, or by bites or scratches from infected animals. Between people mainly through close contact transmission, but also in a long time in close contact through droplet transmission, contact with the virus contaminated items may also be infected. This monkeypox outbreak also found that most of the cases had same-sex sexual behavior before the onset of the disease, which may still be mainly related to close contact transmission during sexual activities, and it is not yet certain whether the virus will be transmitted through semen or vaginal secretions. Monkeypox virus can also be transmitted from a pregnant woman to her fetus through the placenta.