Liver abscess 1 month hardly eliminated may be due to improper use of drugs such as antibiotics not covered, resistant or ineffective, abscess cavity is too large, wrong diagnosis. 1.Liver abscess 1 month if after treatment almost no shrinkage elimination may be related to the improper use of drugs. This may include incomplete coverage with empiric antibiotics such as penicillin, resistance of the infection to the antibiotics used, or a fungal or amoebic infection rather than a bacterial infection. In this case, it is necessary to re-examine the pathogenic bacteria and drug sensitivity test, change antibiotics or use antifungal drugs such as amphotericin B or anti-amoebic drugs such as metronidazole. 2. Liver abscess is more serious, the pus cavity is too large, and the number of pus cavity is too large, at this time, the efficacy of antibiotics alone is poor, and it is necessary to carry out abscess drainage or surgical resection, in order to have a better therapeutic effect. 3. Wrong diagnosis. It may not be a simple liver abscess, there may be immune, tumor factors, conventional treatment does not work. Therefore, it is necessary to be diagnosed and treated under the guidance of a professional physician to avoid delaying the condition and causing accidents.