The method of glucocorticoid dose reduction should be decided according to whether the disease is relatively stable, the amount of hormone used, and the duration of glucocorticoid use; each patient’s condition is different, and the method of dose reduction varies from person to person. Usually the dose is gradually reduced after 2 weeks when the clinical symptoms of the disease have basically disappeared, usually 3 to 4 weeks after the drug is used. Although there are various methods of dose reduction, the principle of dose reduction is the same, that is, to reduce to the minimum effective maintenance amount according to the condition. If prednisone is used above 40 mg per day and the disease is relatively stable, the dose can be reduced by 5-10 mg to 30 mg/day per week or every 2 weeks, and then by 2.5-5 mg to 15 mg/day every 2-4 weeks, and then more slowly. The dose can be reduced even if the antinuclear antibody titer does not decrease. Some advocate reducing the dose every other day, and when it is reduced to .15-20 mg/day, the dose may be reduced every other day until there is a day when no dose is given. This method preserves or restores hypothalamic-pituitary-adrenal axis function with less tendency to osteoporosis, Cushing’s face and infection than taking the same total dose daily, and facilitates growth and development in children. Another advantage is that it facilitates the detection of symptoms of disease activity, which usually appear the next – morning before taking the medication, which suggests the possibility of relapse. For some rheumatic diseases such as SLE, glucocorticoids are usually taken for a longer period of time or even for the rest of life, so the purpose of dose reduction is also to find the minimum maintenance dose that can control the disease and to minimize hormonal adverse effects. If the reduction of hormone dosage is not successful for a long period of time, or if the disease recurs during the reduction process, immunosuppressive drugs should be added early.