Closed injection is also an invasive operation, which usually mixes a certain concentration and quantity of prednisolone injection with procaine hydrochloride and injects it into the lesion area, in the muscles, joints, fascia, tendons and even in the spinal canal. Pain is noticeable during the closure injection, and this is the main reason why patients are reluctant to receive it. The local pain is slightly aggravated by the injury as well as within 1-2 days after the closure. This is related to the increased local pressure stimulated by the drug, but it will soon disappear. Because the closed injection with hormones, so it and all drugs, there are side effects, such as centripetal obesity, body shape change, hairy skin, and can lead to the body’s ability to resist infection, wound healing slowed, but also easy to aggravate gastric ulcers, induced hypertension, psychosis, aseptic necrosis of the femoral head, osteoporosis, etc.. These are phenomena that occur only after repeated application of large doses over a long period of time, and generally short-term local closed therapy will not cause these reactions, but should be used with caution for patients with these diseases. In order to prevent infection, closed injection should be carried out in regular medical units, before the closure of the skin washed with soap and water, strict disinfection, 15 minutes after the injection observation, to prevent allergic reactions and other reactions. At the same time, the local injection site should be kept clean within three days after the closure, and the change of medication should be strengthened to prevent infection. These are its side effects, but they are relatively rare.