Adrenocorticotropic hyperplasia is treated by surgical, radiologic, and pharmacologic methods to eradicate the lesion itself. Drug therapy is usually based on drugs that block the synthesis of adrenocorticotropic hormone, such as mitotane and metipranolone. For patients who are not well treated with medication, surgical treatment can be chosen. Surgical treatment varies according to the cause of the disease, such as the removal of pituitary microadenomas for those whose lesions are in the pituitary gland, or the removal of adrenal adenomas for those whose lesions are in the adrenal glands, etc. Radiation therapy is suitable for postoperative pituitary residuals. Radiation therapy is suitable for patients with pituitary microadenomas who have residual lesions after pituitary surgery and refuse surgical treatment. Hypercortisolism is controlled in 50% to 60% of the patients within 3 to 5 years after treatment. Hypopituitarism may be complicated and regular follow-up is needed. Patients with hypercortisolism of the adrenal cortisol should go to the hospital in time and standardize the diagnosis and treatment under the guidance of doctors.