The following reasons need to be considered for chest pain when sleeping: 1, heart diseases, such as coronary heart disease, unstable angina, etc., because the vagus nerve tone increases, heart rate slows down and blood vessels contract during sleep, resulting in insufficient blood supply to the coronary arteries, thus patients wake up with chest pain, especially long-term hypertensive patients, it is recommended that such patients undergo 24-hour ECG monitoring to clarify the cause and give timely treatment. 2, pulmonary diseases such as bronchial asthma, pneumonia, pulmonary tuberculosis, etc. For patients with asthma who exhibit chest pain and wheezing-like breathing, and patients with pneumonia and tuberculosis who, in addition to chest pain, have symptoms of coughing, coughing up sputum and coughing up blood, need timely lung CT and sputum culture to clarify the cause and give timely symptomatic treatment. 3, gastroduodenal ulcer, in addition to chest pain after waking up, manifests as pain under the glabella or hunger pain after eating. It is recommended to do gastroscopy to clarify the diagnosis.