The causes of headache despite radiotherapy for glioma include cerebral edema, side effects, incomplete removal of tumor, etc. It is suggested to treat the cause of the disease, such as drug treatment, daily care and so on. 1. Cerebral edema: In the process of treating glioma through radiotherapy, it is inevitable to cause damage to brain tissues, which will lead to cerebral edema and headache symptoms. For this situation, medicines can be used for treatment under the guidance of medical personnel, and the common ones are mannitol, furosemide, albumin and so on. 2. Side effects: radiotherapy will stimulate the nerve tissues in the brain, resulting in abnormal nerve function and headache and muscle pain. It is recommended to follow the doctor’s instructions and take drugs that nourish the nerves for treatment, such as vitamin B1, methylcobalamin and so on. Secondly, during the period of treatment, we should strengthen the nursing work, pay attention to more rest and eat more protein-rich food. 3. Tumor is not completely removed: some patients have large tumor size, which is difficult to completely subside; or recurrent attacks, headache symptoms may be accompanied by lifelong. Continuous radiotherapy and chemotherapy according to the course of treatment are needed to control the symptoms. Brain glioma is a more serious disease, which requires timely consultation and active treatment. During the period of discomfort should consult the doctor in time, under the guidance of the doctor timely disposal.