Clinically, if a diabetic patient has numbness in the toes, it often indicates the presence of diabetic peripheral neuropathy, and the following dispositions need to be given: 1. Monitor blood glucose. The presence of diabetic peripheral neuropathy in patients is mainly related to prolonged substandard blood glucose control, so monitor blood glucose early and adjust the glucose-lowering program to bring blood glucose control up to standard in order to reduce the damage of high blood glucose on diabetic peripheral nerves. 2. Give nutritional The main clinical drugs are methylcobalamin, lipoic acid and epalrestat, which can achieve the effect of early nerve repair, early treatment and early benefit. 3. Appropriate drug therapy to improve circulation can improve the symptoms of numbness of toes to a certain extent.