Dry syndrome is a diffuse conjunctival tissue disease characterized by invasion of exocrine glands such as lacrimal and salivary glands with lymphocytic infiltration and specific autoantibodies. The main clinical manifestations are dry keratoconjunctivitis and oral dryness, but it can also involve other organs and present complex clinical manifestations. The prevalence is 0.5%-1.56% in adult women, and the ratio of men to women is 1:9-1:10. The disease can develop at any age, including children and adolescents, and the age of prevalence is 30-60 years old, accounting for about 90% of all cases. Most scholars believe that infection, genetics, endocrine and other factors are involved in the occurrence and continuation of this disease. Dry syndrome mainly involves the exocrine glands composed of columnar epithelial cells. It is represented by salivary glands and lacrimal glands, which show massive lymphocytic infiltration in the glandular interstitium, dilation and narrowing of the glandular ducts, and destruction and atrophy of epithelial cells in minor salivary glands. It is mainly divided into local and systemic manifestations. Local manifestations: 1. Dry mouth: 70%~80% of patients have dry mouth, and those who are serious need to drink water frequently when they speak, and need to be accompanied by liquid to send down when eating solid food. Some patients will have rampant dental caries, the teeth gradually become black, followed by small pieces falling off, and finally only the residual roots remain, which is one of the characteristics of this disease. About 50% of patients have intermittent swelling and pain in the parotid gland, involving unilateral or bilateral. Some patients will also have tongue pain, dry and cracked tongue, and atrophy of the tongue papillae. 2, dry keratoconjunctivitis: symptoms such as dry eyes, foreign body sensation, less tears, or even no tears when crying, due to the reduction of mucin secreted by the lacrimal glands, and in severe cases, corneal ulcers. 3. Other superficial sites: such as the nose, hard palate, trachea and its branches, mucosa of the digestive tract, and exocrine glands of the vaginal mucosa can be involved, resulting in corresponding symptoms. Systemic manifestations: 1. Skin: about 1/4 of patients have different rashes, manifested as purpura-like rash, mostly in the lower limbs, the size of rice grains, appearing in batches. There may also be urticaria-like rash, erythema nodosum, etc. 2, skeletal muscle: arthralgia is more common, 70% to 80% of patients have arthralgia, of which 10% have arthrosis, mostly not serious, and transient. 3, kidney: 30% to 50% of patients have kidney damage, mainly involving the distal renal tubules, manifested as peripheral hypokalemic paralysis due to renal tubular acidosis, and in severe cases, renal calcification, renal stones, renal uremia and renal chondromalacia. 4, respiratory system: bronchitis, pulmonary maculopathy, interstitial pneumonia, etc., and even pulmonary hypertension, a few patients may die of respiratory failure. 5, digestive system: gastrointestinal mucosal layer exocrine gland lesions and non-specific symptoms such as atrophic gastritis, decreased gastric acid, chronic diarrhea. Liver damage is seen in about 20% of patients. 6. Nervous system: Both peripheral and central nerves can be involved, but peripheral nerve damage is more common. Sensory and motor nerve abnormalities, mild hemiparesis, and transverse myelopathy may occur, and aseptic meningitis, optic neuromyelitis optica, and multiple sclerosis have also been reported. 7. Hematologic system: Leukopenia or (and) thrombocytopenia may occur. The incidence of lymphoma is significantly higher with the normal population. Therefore, when similar symptoms appear, promptly go to regular hospitals for early diagnosis and treatment to avoid delaying the disease.