Lumbar puncture is a commonly used invasive clinical examination, which has certain hazards or complications, roughly the following: 1, headache: after releasing part of the cerebrospinal fluid by lumbar puncture, no effective infusion is performed, which can produce a decrease in the amount of cerebrospinal fluid in the subarachnoid space and a decrease in intracranial pressure, thus producing intracranial vasodilation and causing headache; 2, infection: local puncture is an invasive operation, which can bring external bacteria to the subarachnoid space, thus This can easily cause septic infection and, in serious cases, septic meningitis; 3. Hemorrhage: especially when the patient has abnormal coagulation function, it can cause bleeding at the puncture site; 4. Nerve damage: inaccurate operation of lumbar puncture can cause damage to the nerve root or cauda equina. Therefore, the hazards of lumbar puncture are rather typical, but these problems can be avoided with proper clinical operation.