Is there generally a big difference between biopsy and postoperative pathology?

It is possible that the results of the biopsy may differ from those of the postoperative pathology. If the more suspicious tissue is not completely removed during the biopsy, it may be missed during the test, and the results may differ from those reported in the postoperative pathology report. However, if the pathologic tissue is removed more accurately during the biopsy, the results are generally the same as the postoperative pathology results. Biopsy mainly refers to the extraction of diseased tissue through puncture and other methods for pathological examination; postoperative pathology generally refers to the removal of a certain amount of diseased tissue as a specimen for pathological testing during surgery. The amount of lesion tissue extracted by biopsy is relatively small, and there may be a certain amount of suspicious pathological tissue not removed, which may cause test omission and affect the examination results; the pathological tissue removed by postoperative pathology is relatively more complete, with a relatively low rate of leakage, and its pathology report is more comprehensive, which can reflect the size of the pathological tissue, depth of infiltration, and margins. The accuracy rate of biopsy is more related to the specimen taken at the time of puncture, and there is a certain rate of misdiagnosis and leakage. The accuracy of postoperative pathology is relatively high, but it needs to be performed during surgery, which is more damaging to the body.