Bedridden elderly people with broken skin on the buttocks can use medicines such as fusidic acid cream, mupirocin ointment, rehabilitation new liquid and growth factor spray. Fusidic acid cream and mupirocin ointment belong to the anti-infective drugs, can be used to prevent and treat infections, before applying the need to go to the hospital to the patient’s buttocks of purulent secretions as well as blackened and necrotic tissues clean up, followed by disinfection of the wound site, and then apply the ointment. Rehabilitation new liquid and growth factor spray belong to the growth-promoting drugs, which can promote the healing of wounds, improve the status quo of broken skin and erosion of wounds, and can also make the wound site grow new muscle and skin tissue. In order to avoid bedsores and skin breakouts, long-term bedridden elderly people are best to use air mattresses, in the use of medication, must follow the doctor’s instructions, the rational application of drugs, do not arbitrarily use the drug, to avoid causing adverse reactions.