Psychophysiologic insomnia is a primary type of insomnia caused by the patient’s excessive preoccupation with sleep problems, also known as insomnia, in which the patient shows persistent dissatisfaction with the quality and quantity of sleep for a considerable period of time, resulting in apprehension or fear and a vicious cycle of psychological persistence of the disorder. Insomnia can be triggered by emotional conflicts from any cause, or can be caused by factors such as jet lag from travel or short-term hospitalization. The patient’s personality before the disease is often characterized by sensitivity, high alertness, excessive health demands, irritability, and impatience. The lifetime prevalence of the general population is about 10-20%, the disease is rare in children and adolescents, and the onset of the disease mostly begins in youth (20-30 years old), and gradually becomes obvious and increases after middle age, and is common in women. About 15% of patients with insomnia try to fall asleep the more they can’t, and the closer they get to sleep, the more excited or anxious they seem, forming a vicious circle. The idea of trying to fall asleep becomes a driving factor for insomnia, while watching TV or reading a book may make it easier to fall asleep (unconscious sleep). Extrinsic factors that contribute to insomnia include the persistence of an environment that makes it difficult to produce sleepiness and a lack of associations with sleep-related behaviors. Excessive arousal that is incongruent with sleep arises due to the recurrent association of insomnia with sleep environment, sleep duration, and behavioral stimuli during sleep. The bedroom becomes an important factor of conditioned arousal, and as long as one is in one’s own bedroom, one can not sleep all night. If one changes the sleep environment or time, such as on the sofa in the living room or in a hotel, one can fall asleep better, and patients often feel very confused about this, which is exactly the opposite of the phenomenon that people with normal sleep cannot fall asleep well in an unfamiliar environment, called the first-night reversal effect. This is the opposite of a normal sleeper’s inability to fall asleep in an unfamiliar environment. The course of the disease lasts for years or decades. Some patients experience hypnotic overdose, dependence, addiction or alcoholism, or abuse stimulants in an attempt to control daytime fatigue. Polysomnography shows reduced sleep efficiency, prolonged sleep latency and NREM sleep stage 1, increased awakenings, shortened NREM sleep stages 3 and 4, muscle tension and first-night reversal effects. The diagnosis is based on the patient having a learned sleep-blocking association, conditioned arousal to bedroom or sleep-related behaviors, which can be characterized by unconscious sleep onset, somatic tension and first-night reversal effects, and can coexist with other types of insomnia. Diagnosis: Based on the patient’s acquired sleep-blocking associations, conditioned arousal to bedroom or sleep-related behaviors, which can be characterized by unconscious falling asleep, somatic tension and first-night reversal effects, and can coexist with other types of insomnia. Treatment: I. Medication: Medication is a commonly used and proven more effective treatment method. Benzodiazepines, zolpidem, zopiclone, dezopiclone, antidepressants, etc. Second, non-pharmacological treatment 1, psychotherapy. 2, biofeedback, can strengthen self-relaxation training, for reducing anxiety effective. 3, physical exercise: appropriate physical exercise, enhance physical fitness, aggravate the sense of somatic fatigue, sleep is appropriate. But the amount of exercise is not easy to too much, excessive fatigue but affect sleep. 4, adjust the habits of life, such as the abolition or reduction of naps, to develop the habit of timely sleep.