The best time to take Metformin Glibenclamide is with food, as directed by your doctor. Metformin Glibenclamide is a combination of Metformin and Glibenclamide and is suitable for use in type 2 diabetes mellitus in which blood glucose levels cannot be controlled satisfactorily by diet, exercise therapy or monotherapy alone. The drug is generally recommended to be taken with a meal, and adverse reactions such as nausea, vomiting, diarrhea, and abdominal pain may occur after administration. Contraindications to the use of the drug include hypersensitivity to metformin or glibenclamide, type 1 diabetes mellitus, renal disease or renal insufficiency, acute and chronic metabolic acidosis, congestive heart failure requiring medication, prior to venous pyelography or arteriography, or major surgery, or clinical hypotension, hypoxia. Specific medications should be administered under the guidance of a specialist.