Flumazenil is a psychotropic drug that is still widely used in clinical practice. However, flumazenil has many important side effects, mainly including effects on the cardiovascular system and possible induction of seizures. Some studies have concluded that flumazenil intravenous drip resulted in a transient increase in heart rate, blood pressure, and pulmonary artery pressure, and a significant increase in the product of left ventricular ejection fraction, heart rate, and blood pressure. This is due to increased sympathetic activity or antagonism of the cardiovascular depressant effect of midazolam, which ultimately leads to increased myocardial oxygen consumption; therefore, flumazenil is not recommended for patients with coronary artery lesions. In addition, flumazenil may induce seizures in patients with long-term benzodiazepine use or overdose of tricyclic antidepressants.