Inflammatory spinal cord demyelinating disease is generally referred to as demyelinating disease, and it is impossible to generalize whether patients with demyelinating disease can be vaccinated. If there are no contraindications to the components of the vaccine and the patient is not in an acute exacerbation of the disease, the vaccine can usually be administered. However, if the patient has contraindications to vaccination or is in an exacerbation of the disease, vaccination is generally not allowed. Causes of demyelinating diseases include genetic predisposition, inadequate vitamin D intake, trauma, and emotional stress. Patients with demyelinating diseases often have symptoms such as vision loss, limb weakness, sensory abnormalities, ataxia, urinary and fecal disorders, and varying degrees of impaired consciousness. Whether patients with demyelinating diseases can be vaccinated cannot be generalized due to the type of vaccine and individual circumstances. If patients with demyelinating diseases are recovering from the disease and there are no obvious contraindications to vaccines, vaccines can usually be given under the supervision of a doctor, and any adverse reactions can be observed after the injection. When some patients are in the period of disease flare-up, vaccination at this time may lead to disease aggravation, and may also cause new diseases, which will damage the health of the body, and vaccination is not recommended in this case. Therefore, before vaccination, patients should take into account their own situation and ask the doctor’s advice.