Herpes pubis, possibly the presence of genital herpes, can be treated with topical as well as oral medications. Examples include 3% acyclovir cream and vasiclovir. For genital herpes, washing with physiologic sodium chloride solution and treatment with topical antiviral medications such as 3% acyclovir cream and 1% penciclovir cream can be used to eliminate the infection and improve the discomfort. Oral medications such as acyclovir and valacyclovir can also be used. During the treatment period, it is necessary to take good care of the daily life, avoid sexual intercourse, maintain hygiene of the lower body, wash the lower body diligently, do not scratch the lower body excessively, and change the cotton loose underwear. When using medication, it is important to follow the doctor’s instructions, rational application of external as well as oral medication, to avoid improper use of medication causing serious adverse reactions.