Difficulties in the treatment of nail psoriasis: 1. slow response to treatment; 2. conventional treatment methods are generally difficult to implement and ineffective; 3. individual cases of stubborn nail removal may be required. Current methods of nail psoriasis treatment: 1. Local treatment: penetrating gels, lacquers, foam gels and sprays can be used to facilitate the absorption of drugs. Commonly used topical drugs include: glucocorticoids (alone or in combination with salicylic acid), carbotriol and other vitamin D derivatives and compound preparations, tazarotene and urea. If emulsion formulations are used encapsulation therapy should be used. Topical medications are indicated for less involved nails, light damage and the need for long-term treatment. 2.Injections within the lesion: glucocorticoids diluted with lidocaine and injected slowly and superficially. 3.Phototherapy: NB-UVB phototherapy, PUVA phototherapy, pulsed dye laser and photodynamic therapy. 4.Systematic medication: Severe nail psoriasis should be treated systematically, and the effective drugs include MTX, cyclosporine and Avia. Among the three systemic treatment drugs, cyclosporine has more obvious efficacy on nail psoriasis. 5.Systematic application of biological agents: biological agents for the treatment of nail psoriasis include: adalimumab, alefacept, etanercept, infliximab and ustekinumab. Among them, infliximab has shown advantages in the treatment of nail psoriasis. Different types of nail psoriasis have shown rapid and significant improvement after treatment with infliximab. Infliximab is currently one of the most effective therapeutic agents for the treatment of nail psoriasis. Figure 1 Evaluation of the effectiveness of infliximab in the treatment of nail psoriasis (24 weeks of treatment)