Typically, hepatitis E usually resolves spontaneously in 30-90 days, depending on the individual. Hepatitis E is a self-limiting disease, an infectious disease caused by infection with hepatitis E virus, which usually manifests itself in symptoms such as fatigue, loss of appetite, anorexia, and deepening of urine color. Hepatitis E virus is mainly transmitted via fecal-oral route and is most common in young adults and middle-aged and elderly people. The self-healing time of hepatitis E is related to the patient’s immunity. If the patient is a young adult or has strong immunity, the disease can usually be self-healed in 30-90 days; if the patient is a middle-aged or elderly person or has weak immunity, the disease can usually be self-healed in 90-180 days. In the former case, it is possible to recover in 30-90 days without treatment; in the latter case, medication is required for recovery. It is recommended to consult a doctor in time, under the guidance of the doctor, to carry out reasonable and standardized treatment, to avoid the deterioration of the condition.