The difference between gonorrhea and nongonococcal urethritis includes differences in etiology, symptoms, ancillary tests, and treatment. 1. Causes:Gonorrhea is caused by Neisseria gonorrhoeae infection, which is mainly transmitted through sexual contact; non-gonococcal urethritis is mainly caused by infection by pathogens other than gonococcus, which can be transmitted through sexual transmission, indirect contact transmission, and vertical transmission from mother to child. 2. Symptoms: gonorrhea often have frequent urination, urinary urgency, urinary pain, urethral or vaginal abnormal discharge and other symptoms, male gonorrhea with posterior urethral involvement, there may be terminal hematuria, hematospermia, mild swelling of the perineum and other symptoms of painful erection of the penis at night; non-gonorrheal urethritis manifested as painful urination, increased urethral secretion, male urethral orifice tingling, stinging, or burning sensation and so on. 3. Auxiliary examination: gonorrhea through the secretion to do smear examination, can be seen in the white blood cells gram stain negative diplococcus, do gonococcal culture, can be seen in typical colonies, gonococcal nucleic acid in the specimen test was positive, etc.; non-gonorrheal urethritis blood test found that the white blood cells and neutrophil counts are increased, the urethral secretion smear, can be seen in the Chlamydia trachomatis inclusion bodies, etc.. 4. Treatment: Gonorrhea generally use cephalosporin antibiotics, such as ceftriaxone, cefotaxime, etc., can not accept cephalosporin, can use macrolide; non-gonorrheal urethritis treatment using tetracycline antibiotics, such as tetracycline hydrochloride, doxycycline, etc., macrolides, such as azithromycin, clindamycin, etc., quinolones, such as levofloxacin, moxifloxacin, etc. treatment. It is recommended that patients go to regular hospitals and follow the doctor’s instructions for reasonable medication.