The normal reference range for syphilis TRUST titer is 1:1 negative.
Syphilis is a sexually transmitted disease (STD) caused by syphilis spirochetes that jeopardize human health. The invasion of syphilis spirochetes into the human body can stimulate the production of two types of antibodies: anti-syphilis spirochete-specific antibodies and a non-specific antibody. In order to improve the diagnostic rate of syphilis, the clinic usually combines the Toluidine Red Unwarmed Serum Test (TRUST) and the syphilis spirochete gelatin agglutination test (TPPA) to carry out the detection of two methods.
TRUST is a non-specific antibody test for syphilis, which mainly measures cardiolipin antibodies in serum. The antibody can be positive at the onset of syphilis infection and turn negative after cure, which is used to determine the severity of the disease, treatment effect, and disease regression, and belongs to the screening test for syphilis spirochete infection, with a normal reference value of 1:1 negative, and the higher the titer of TRUST, the more severe the disease may be, or at an early stage.
Non-syphilitic diseases can produce liposome-like antibodies that react with phospholipid antigens to produce false-positive TRUST results; the TRUST method is also not applicable to early stage 1 syphilis, stage 3 syphilis, and is not sensitive to latent syphilis and neurosyphilis, resulting in false-negative results.
Therefore, it is recommended that the patient should consult a doctor in time, and combine the symptoms, TRUST and TPPA test results to determine the patient’s infection status.