The down-regulation injection can effectively adjust the level of luteinizing hormone during the follicular phase and may improve the quality of ovulation. The second day of menstruation, the down-regulation injection, usually does not cause significant effects on menstruation. The down-regulation injection has a certain inhibitory effect on the growth and development of follicles, and may encourage follicles to develop at the same level. With the use of ovulation injections, follicle maturation is generally promoted and mature follicles discharge eggs. Descending injections do not have a direct effect on menstruation, so a descending injection on day 2 of the period may not significantly affect menstruation. If a woman has irregular menstruation when she takes the hypospadias injection on the 2nd day of her period, it may be a manifestation of various pathogenic factors such as endocrine disorders, abnormal ovarian function, and so on. Appropriate treatment under the guidance of professional doctors is needed according to the different causes of the disease, which is conducive to the improvement of the condition.