High-grade intraepithelial neoplasia of colon polyps is a serious atypical hyperplasia, which belongs to the precancerous lesions of colon cancer, and needs to be treated in time. High-grade intraepithelial neoplasia of colon polyps is usually caused by environmental factors, poor dietary habits and chronic inflammatory stimulation of the intestinal tract. Pathologically, it is a condition in which heterogeneous cells occupy the entire epithelial cell layer. On common examination, bulging or ulcerated lesions are observed, with a fixed base of the tumor and involvement of the intestinal canal. The occurrence of high-grade intraepithelial neoplasia of the colon polyps should be treated promptly with early therapeutic intervention. If the polyp is small and has a tip, it can be resected under enteroscopy; if the polyp is directly larger and the base is more extensive, laparoscopic resection of intestinal segments is feasible, and the specific treatment modality will be chosen by the specialist after clarifying the condition. The occurrence of colonic polyps high-level intraepithelial neoplasia, should be timely medical treatment, under the guidance of specialists to actively carry out appropriate treatment, in accordance with the doctor’s instructions, will help to cure the disease as soon as possible.