Chronic hepatitis B (abbreviated as hepatitis B) refers to those who test positive for hepatitis B virus and have a clinical manifestation of chronic hepatitis with a disease duration of more than six months or an unclear onset date. The therapeutic goals of chronic hepatitis B 1. long-term inhibition of hepatitis B virus replication 2. reduce stem cell inflammation necrosis and fibrosis 3. reduce the occurrence of cirrhosis and liver cancer. Anti-viral is the key to hepatitis B treatment 1. Hepatitis B virus is difficult to be completely eradicated 2. The continuous replication of hepatitis B virus is the culprit of cirrhosis and liver cancer 3.