The scientific name of diffuse large B-cell lymphoma is diffuse large B-cell lymphoma, and its treatment course is related to the stage of the disease, drug regimen, individual factors, etc., and it is not certain that the tumor can disappear in a few courses of treatment. At present, diffuse large B-cell lymphoma is often treated with chemotherapy combined with targeted drugs, and those without large masses in early stage need 4 cycles of chemotherapy, those with large masses need 6-8 cycles of chemotherapy; those in middle and late stage need 6-8 cycles of chemotherapy. In the course of treatment, the efficacy of the treatment should also be evaluated to see if complete remission has been achieved, and if it has not been achieved, it is necessary to change the treatment regimen or undergo hematopoietic stem cell transplantation. Specific therapeutic agents include rituximab, cyclophosphamide, vincristine and dexamethasone. The overall prognosis of diffuse large B-cell lymphoma is good, but there are still some patients who cannot be cured, or the disease recurs after treatment to achieve remission, therefore, even after remission, the disease should be reviewed regularly. Specific diagnosis and treatment should be carried out under the guidance of a physician.