The R-CHOP regimen is currently the most commonly used and most classical regimen in the treatment of non-Hodgkin’s lymphoma, especially diffuse large B-cell lymphoma, and is highly effective. The specific method of use is to start with oral prednisone tablets, a hormonal drug, for at least five days. The next step is to use rituximab, also known as melphalan, and after rituximab, the next step is to use adriamycin, and after adriamycin, then cyclophosphamide, and after cyclophosphamide, then vincristine. During the whole process, we have to pay attention to the protection of the veins, some of them are injected by hanging vials, some of them are injected by large syringes. After all the drugs are used, the catheter is also flushed with sodium chloride injection to ensure that the drugs enter the body completely, which is roughly the order of the R-CHOP program. The specific side effects of the medication and the management of adverse reactions should be left to the specific doctor and nurse in charge.