Itching after using tacrolimus ointment may be a normal symptom, it is recommended to wait for the drug to be absorbed; if the itching persists it is recommended to stop using it, rinse with water and seek medical attention. At the beginning of the use of tacrolimus ointment may cause some local symptoms, the most common is the burning sensation or itching of the skin, this is a normal phenomenon, wait for the absorption of the drug can be, do not need to carry out special treatment, usually with the improvement of skin symptoms and disappear. Generally with 0.1% tacrolimus ointment, 90% of the itching lasts between 3 minutes and 10 hours. If the itch persists or worsens after a period of time, it may be due to an allergy to the ingredients in the ointment. It is recommended to stop using the ointment, rinse the area where the ointment is applied with water to relieve the itch, and go to the hospital for a follow-up examination to have the doctor assess whether to change the use of the medication.