The majority of syphilitic tongue manifestations do not have typical symptoms. The damage may appear as one or more well-defined erythema, edema, vesicles, or painless nodules. In the early stages of syphilis, lesions of the oral mucosa can be present. Mainly in the oral mucosa, tongue and throat, the common manifestation is one or more flaky, clear boundary erythema, edema, vesicles, the surface can have gray-white membrane. In advanced syphilis, that is, the third stage of syphilis, some syphilitic trephines can also occur in the oral cavity. It is manifested as a localized painless nodule, and then gradually the central softening, ulceration, the appearance of viscous gum-like secretion, so that after the discharge of secretion, the localization will form atrophic scars. This damage to the oral cavity can cause difficulty in eating. It is recommended that patients diagnosed with syphilis should be treated early, and standardized medication should be used throughout to avoid serious complications.