Bitterness in the mouth is caused by a variety of reasons, and should be handled differently according to different reasons, as follows: 1, oral system diseases: such as gingivitis, calculus, oral infections, will be accompanied by bitter mouth symptoms, need to deal with the original disease, to the stomatology department, the inflammation will be resolved will be better; 2, digestive system diseases: too much food or rice in the gastrointestinal stay too long, resulting in indigestion. On the one hand, it is necessary to eat less diet and reduce the quantity of meals by half; on the other hand, it is possible to use drugs to clear stomach fire to relieve the symptoms of bitterness, such as Huanglian Pill or Huo Xiang Qing Stomach Pill; 3, liver and biliary system diseases: such as bile reflux gastritis or gallstones, after gallbladder removal, it is possible to use herbs to clear liver fire, such as Gentian Diarrhea Liver Soup and Gentian Diarrhea Liver Pill; 4, systemic diseases: such as diabetes, cancer patients, the oral sweet taste threshold rises and the bitter taste threshold The main reason is to treat the original disease; 5. Mental bitterness: life is fast-paced, life is stressful, accompanied by fatigue, staying up late and poor sleep. Change the lifestyle mainly, such as do not work hard, stay up late, do not eat spicy, fire food.