Ankylosing spondylitis is usually incurable and may progressively worsen. However, if there is no underlying disease, life expectancy is usually not affected, and symptoms can be relieved and quality of life can be improved through general treatment, medication and surgery. Ankylosing spondylitis is a chronic inflammatory disease that involves the sacroiliac and spinal joints, mainly manifested by pain and stiffness in the lower back or buttocks, which can affect normal life and cause disability, but active treatment usually does not affect life expectancy. Drug treatment is mainly to relieve the symptoms, for example, non-steroidal anti-inflammatory drugs are currently the first choice of drugs for the treatment of ankylosing spondylitis, which can rapidly improve the symptoms of low back pain, morning stiffness, joint swelling and pain, such as celecoxib, meloxicam, and loxoprofen sodium. If the patient has obvious narrowing of the hip joint space, necrosis of the femoral head as well as spinal curvature deformity obviously affecting the quality of life, surgery can be taken. At the same time, patients in their daily life is mainly to strengthen the care of ankylosing spondylitis, strengthen the exercise, correct the bad sitting and standing posture, avoid long-term work at the desk, develop good living habits, early to bed and early to sleep, keep a happy mood, and according to the doctor’s instructions for regular review, can improve the quality of life.