Small pimples on the thighs may be caused by acne, folliculitis, contact dermatitis, eczema and other diseases that can be manifested as pimples, and general treatment and medication can be given according to their causes. 1. Acne: due to Propionibacterium acnes infection, sebaceous gland secretion and discharge abnormality, etc. It can be treated with topical medication such as fusidic acid cream, retinoic acid cream, etc., and pay attention to local cleanliness. 2. Folliculitis: the hair follicles on the thighs are infected by bacteria and pimples appear, antibiotic treatment can be given, commonly used drugs are mupirocin ointment, fusidic acid cream, etc., which has the effect of anti-infection; fungal infections, such as Malassezia infection, can also lead to folliculitis, and can be applied locally with amorphophallus ointment. 3. Contact dermatitis: contact dermatitis may be induced by contact with certain substances, resulting in small acne, you can apply hydrocortisone cream, mometasone furoate ointment and other medications. 4. Eczema: may be in contact with certain allergens, causing eczema on the thighs, accompanied by itching and other symptoms, the local can be coated with budesonide cream, oral cetirizine, loratadine and other drugs. There are many possible causes of small pimples on the thighs, and it is recommended that you seek medical attention to identify the cause of the problem and follow the doctor’s instructions. The medication should be used in accordance with the doctor’s instructions, do not self-medicate.