Complications arising from taking targeted drugs in advanced stage of liver cancer need to be positively faced and treated with symptomatic drugs to minimize the impact of complications. Complications arising from taking targeted drugs in advanced stage of liver cancer are drug-related adverse reactions, commonly including hypertension, hand-foot syndrome, diarrhea, etc. Corresponding treatments should be carried out according to the specific symptoms of patients, as follows: 1. Hypertension: patients may have an abnormal increase in blood pressure after using targeted drugs, and need to choose the appropriate antihypertensive drugs based on the blood pressure level and cardiovascular risk, with common drugs such as amlodipine, valsartan, enalapril, and so on. 2. Hand-foot syndrome: patients will mainly have numbness, dullness or pain in the hands and feet, and there will also be skin swelling, erythema, ulceration and so on. Patients to improve the skin care of hands and feet at the same time can use benzylamine cream, mupirocin cream and other symptoms, if the symptoms are serious need to stop under the guidance of a professional physician targeting drugs, replacement of other treatment modalities. 3. Diarrhea: When diarrhea first occurs or is intolerable to the patient, anti-diarrhea medications, such as loperamide hydrochloride capsules, can be used appropriately. If symptoms cannot be relieved after symptomatic treatment, the drug should be reduced or stopped. In addition to the above symptoms, patients may also have skin rashes, mouth ulcers, liver damage and other adverse reactions occur, it is recommended that patients should be treated under the guidance of a doctor after the occurrence of the above symptoms, do not blindly use the drug.