Playing ball blisters is usually due to local mechanical friction, can be dealt with through general treatment, drug treatment and other ways. 1. General treatment: If the blisters are relatively small, you can use a towel to apply hot compresses to make the water quickly absorbed and promote the recovery of the blisters. 2. Medication: If the blisters are large and have pus, it is recommended to sterilize them with iodine povidone under the guidance of a doctor, and then use a sterile needle to puncture the blisters, so that the pus can flow out. After puncturing the blister, you need to use antibacterial ointment, such as mupirocin ointment, under the guidance of the doctor. And with the use of antibacterial drugs, such as cefixime, amoxicillin, etc.. In addition, prolonged walking and strenuous exercise should be avoided during the recovery period. Keep the local skin clean and hygienic to avoid infection. Specific medication and disposal should be carried out under the guidance of professional doctors.