Oral antidotes are usually taken 30 minutes before drinking, which can play a role in preventing alcohol overdose, and gastric mucosa protectors can reduce alcohol absorption. Oral antidotes include vitamin C, liver protection tablets, diuretics, etc. These drugs can be quickly absorbed by the gastrointestinal tract, thus blocking the absorption of ethanol or promoting the excretion of ethanol to achieve the purpose of alcohol detoxification, while the effect of appropriate supplemental sugar and water is more. But the best way to solve the effect of alcohol is still the injection of alcoholic drugs, reduced glutathione. For alcohol-induced coma, commonly used are naloxone injections, which can quickly pass the blood-brain barrier and decompose ethanol in the blood to achieve the effect of rapid alcohol detoxification, is a commonly used strong antidote to alcohol poisoning, alcohol overdose have a very good treatment effect. We must pay attention to healthy drinking in our daily life. Heavy drinking is not good for health and may lead to acute gastritis, gastric mucosal damage, alcoholic liver cell damage, and even alcoholic cirrhosis in long-term alcoholism.