The Department of General Surgery of Xinhua Hospital recently successfully performed a case of difficult laparoscopic pancreatic cyst removal. After taking the lead in single-port laparoscopic cholecystectomy, double-scope combined treatment of gastric mesenchymal tumor and laparoscopic radical treatment of gastric cancer, the Department of General Surgery of Xinhua Hospital, with its strong technical strength in minimally invasive surgery, has once again marched into pancreatic surgery, filling the gap of laparoscopic pancreatic surgery in the hospital. Six months ago, Mrs. Gu often felt obvious epigastric distension and pain, and the local ultrasound examination suggested an occupying lesion in the tail of the pancreas, which needed to be surgically removed, and considering her old age and poor health, she took conservative treatment. However, over the past six months, the symptoms have gradually worsened and the tumor in the tail of the pancreas has become bigger and bigger. After many inquiries, Mrs. Gu finally visited Xinhua Hospital. After carefully looking at her films, Dr. Zhaohui Tang, M.D., deputy chief physician of general surgery, diagnosed her with cystic solid occupancy of the tail of the pancreas, and surgery was inevitable. However, because of her old age and weak constitution, she was afraid that it would be difficult for her to tolerate the conventional open surgery, so after consultation and discussion in the department, a minimally invasive method was decided. The technical difficulty of surgical excision through the “keyhole” is unimaginable to the general public. Under the guidance of Dr. Yang Yong, deputy chief of general surgery, Dr. Chaohui Tang and Dr. Zhenyu Hei successfully completed a total laparoscopic resection of a cystic occupancy of the tail of the pancreas with preservation of the spleen, which was 6×7 cm in size. Cystic diseases of the pancreas include true cysts, pseudocysts, and cystic tumors, some of which can become cancerous, and most of which require surgical removal or internal drainage of the pancreatic stomach and intestine. The pancreatic gland is deeply located (behind the stomach) and difficult to reveal. Traditional open surgery requires a large surgical incision, great trauma, long hospital stay and many complications such as incisional infection, incisional hernia and intestinal adhesions. With the development of laparoscopic technology, laparoscopic pancreatic surgery has gradually emerged. Because the tail of the pancreas is close to the splenic hilum and the splenic artery and vein are partly in the pancreatic parenchyma, most of the early pancreatic body-caudal resections are combined with splenectomy, but the spleen is an important immune organ of the human body, and laparoscopic pancreatic body-caudal resection with preservation of the spleen is undoubtedly the best choice in the background of no lesions in the spleen. Completely laparoscopic pancreatic cystectomy with preservation of the spleen is internationally recognized as one of the most difficult procedures in laparoscopic surgery, which is difficult, risky and requires the operator to have rich experience and skills in laparoscopic surgery, and the number of cases performed at home and abroad is relatively small at present. Dr. Zhaohui Tang introduced that with the continuous maturation of surgical techniques and equipment, laparoscopic techniques have been gradually applied to the diagnosis and treatment of pancreatic diseases in the past 10 years, but due to the possibility of pancreatic leakage and bleeding, laparoscopic pancreatic surgery is much more risky compared with other substantive organ surgery. It is safe and feasible to use laparoscopic pancreatic surgery.