Osteoarthritis that is less severe in the morning and more severe in the afternoon may be related to overexertion, poor rest, weight bearing on the joints, and exposure to cold. Osteoarthritis is one of the most common joint diseases that is characterized by damage to articular cartilage and involves the entire joint tissue. Eventually, degeneration, fibrosis, fracture, ulceration and damage to the entire articular surface of the articular cartilage occurs. It is characterized by joint pain, stiffness, hypertrophy and limitation of movement. Osteoarthritis patients because of overwork, poor rest, joint weight bearing, cold and other factors, will lead to gap narrowing joint surface cartilage friction, aseptic inflammation stimulation, so that the symptoms of joint pain aggravated, thus appearing osteoarthritis morning relief afternoon serious phenomenon. In daily life, we should pay attention to the combination of work and rest, appropriate rest, reduce the weight of the joints and excessive substantial activities, in order to slow down the process of lesions. In addition, you should pay attention to the warmth of the joints and avoid getting cold. Osteoarthritis may be alleviated in the morning and become severe in the afternoon due to other reasons. It is recommended to go to the hospital in time for a complete examination to clarify the cause of the disease and then give targeted treatment or therapy.