Early symptoms of hyperemesis gravidarum are vaginal bleeding after menopause, paroxysmal lower abdominal pain, nausea and vomiting. Grape fetus is mainly due to the placenta’s chorionic trophoblast proliferation caused by a disease, generally divided into complete and partial two kinds, the early symptoms are mainly for menopause, vaginal bleeding, uterus abnormally large, paroxysmal lower abdominal pain, nausea, vomiting, etc., clinically, generally can be through the color ultrasound, blood HCG, pathological examination to achieve the purpose of the confirmation of the diagnosis. Once found after the hyperemesis gravidarum need to early consultation, as early as possible to clear the uterus, and at the same time follow the doctor’s instructions to give penicillin, ceftriaxone and other antibiotics for preventive infection, for the risk of malignancy can be used methotrexate for prophylaxis of chemotherapy, after the clearance of the uterus need to be under the guidance of the physician regular rechecking of HCG, and a year of strict contraception.