Hepatic hypoechoic nodules with well-defined borders are generally considered to be benign lesions occupying the liver, such as hepatic cysts, hepatic abscesses, and hepatic adenomas. Hepatic hypoechoic nodules indicate that there is a space-occupying lesion in the liver, and at the same time, the boundary of the nodule is clear, so it can be roughly judged that the space-occupying lesion is a benign lesion, which is considered more clinically, such as hepatic cysts, hepatic abscesses, hepatic adenomas and other diseases. Although malignant lesions are generally not considered with clear borders, they should be taken into account if the patient has a high-risk history of previous hepatitis or gastrointestinal malignancy. Malignant lesions mainly include primary hepatocellular carcinoma and metastatic hepatocellular carcinoma. Patients are advised to go to regular hospitals and complete further investigations under the guidance of hepatobiliary surgeons, such as enhanced CT, liver puncture biopsy, etc., in order to clarify the nature of the lesion, so as to decide the most reasonable individualized treatment plan.